Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Physicochemical properties of chloroquine hydrochloride Plaquenil suddenly stopping and mania Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Drugs like plaquenil Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Plaquenil Reviews Everyday Health Hydroxychloroquine and phototherapy combination morpheaPlaquenil depression side effectsWill hydroxychloroquine make my cheeks flushChloroquine phosphate resistant malaria Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Hydroxychloroquine Plaquenil. Plaquenil Oral Interactions with Other Medication. An amount of 600 mg of hydroxychloroquine brand name Plaquenil was administered to these patients every day for 10 days. They reported "a significant decrease in viral load". The drug appeared to be responsible for a "rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious". The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. The antimalarial quinine was first used to treat cutaneous lupus in 1834. Subsequent reports in 19 showed good results with another quinine-like drug in the treatment of both discoid and subacute cutaneous lupus. In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s.