Also had to have an occupational health meeting today for my job as not worked for 6 months now and hoping they make me redundant as i can't work as a waitress with ra due to pain and flares in my opinion. (others may do) and i then can get benefits till i find a job i can do with the ra(i am not doing this just for benefits, i hope people understand that) I have now been on Plaq for just over three years and MTX for just under three years. Plaquenil side effects when stopping Hydroxychloroquine and thyroid I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Mar 17, 2019 Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hello thanks for your time. I started both of these ten weeks ago, I'm on 400mg hydroxy and 25mg of methotrexate. Last week I got in such a state about having to take them and it's got to a point where I constantly feel sick because I'm so anxious of having them, so I've been taken off hydroxychloroquine for two weeks so that now I only have medication on a Monday, I thought this would help. My Rheumy suggested MTX and told me it would be months before we knew for sure it would work. The combination works well for me-though I also take a NSAID. I started feeling better about a month after starting plaq-I was also on prednisone at the time-but couldn't get all the way well. Hydroxychloroquine with methotrexate Methotrexate / Hydroxychloroquine Another question. - NRAS, Hydroxychloroquine Uses, Dosage & Side Effects - Plaquenil antibiotic interactionsPlaquenil and lymphomaPlaquenil and hair dye The patients using methotrexate and leflunomide reported lower scores on suicidal ideation than those using hydroxychloroquine and biological drugs. Patients using leflunomide showed less mental health impairment than other groups. Anxiety, depression and suicidal ideation in patients with.. Methotrexate and hydroxychloroquine Rheumatoid Arthritis.. Treatments for Rheumatoid Arthritis. One 6.7% in methotrexate group who showed elevated liver enzymes and the other 7.1% in hydroxychloroquine group who demonstrated drug eruption. Discussion The current study demonstrated higher therapeutic effects of methotrexate than hydroxychloroquine on lichen planopilaris in a 6-month randomized clinical trial. If you aren’t responding to methotrexate after a two-month period, your rheumatologist may try some kind of combination therapy, such as adding sulfasalazine and hydroxychloroquine called triple therapy or adding a biologic drug such as etanercept Enbrel, adalimumab Humira, or infliximab Remicade. Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed.