Chloroquine podocytes

Discussion in 'Canada Pharmaceuticals Online' started by texprofi, 04-Mar-2020.

  1. Deadangel User

    Chloroquine podocytes


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Fully differentiated human podocytes were used in the following experiments. Agents for podocyte treatment included trehalose 10–100 mM, optimum at 50 mM, PAN 30 µg/ml, chloroquine CQ, 25 µm and wortmannin WT, 0.2 µm Sigma-Aldrich, Missouri, USA. GFP-LC3–transgenic podocytes were generated by retroviral transduction of pMX-GFP-rat LC3 as previously described 59, 60. For lysosomal inhibition, human podocytes and IMCD cells were incubated with chloroquine dissolved in PBS 25 μM final concentration for 2, 4, and 6 hours.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine podocytes

    The benzobfluoranthene in the atmospheric fine particulate matter., Trehalose, an mTOR Independent Autophagy Inducer, Alleviates.

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  6. The increased abundance of FITC-albumin in chloroquine treated podocytes indicates that lysosomal inhibition decreases albumin degradation in podocytes. FITC-albumin abundance in MG-132 treated podocytes at 30 and 60 min was not significantly different than FITC-albumin abundance in control podocytes at 30 and 60 min.

    • Podocytes Degrade Endocytosed Albumin. - PubMed Central PMC.
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    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat.

     
  7. NikolasNT New Member

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Hydroxychloroquine Plaquenil Toxicity and Recommendations. Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS Eye screening for patients taking hydroxychloroquine.
     
  8. vab111 XenForo Moderator

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