Chloroquine rheumatoid arthritis mechanism of action

Discussion in 'Canada Pharmaceuticals Online' started by Shob, 24-Feb-2020.

  1. Lady71 Moderator

    Chloroquine rheumatoid arthritis mechanism of action


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Rheumatoid Arthritis and Systemic Lupus Erythematosus. Mechanism of action The mechanisms underlying the anti-inflammatory and immunomodulatory effects of Plaquenil are unknown. Indications and Usage for Plaquenil Malaria. Plaquenil is indicated for the treatment of uncomplicated malaria due to P. falciparum, P. malariae, P. ovale, and P. vivax. The exact mechanism of action for hydroxychloroquine and another antimalarial drug chloroquine in RA is not known, but researchers think these drugs decrease production of a number of different chemicals that are important to the immune response. 3. What are the possible side effects of hydroxychloroquine?

    For prolonged treatment of lupus or arthritis, adverse effects include the acute symptoms, plus altered eye pigmentation, acne, anaemia, bleaching of hair, blisters in mouth and eyes, blood disorders, convulsions, vision difficulties, diminished reflexes, emotional changes, excessive coloring of the skin, hearing loss, hives, itching, liver problems or liver failure, loss of hair, muscle paralysis, weakness or atrophy, nightmares, psoriasis, reading difficulties, tinnitus, skin inflammation and scaling, skin rash, vertigo, weight loss, and occasionally urinary incontinence. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. For short-term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting.

    Chloroquine rheumatoid arthritis mechanism of action

    PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION, Plaquenil - FDA prescribing information, side effects and uses

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  7. Used for long time for rheumatoid arthritis, but because of associated ocular adverse effects, precaution is taken to have eye examination every 4 to 6 month to check retinal changes. Hydroxy Chloroquine. More effective for long term treatment of rheumatoid arthritis as devoid of long term adverse drug reactions, especially eye changes.

    • Chloroquine – howMed.
    • Treatments for Rheumatoid Arthritis.
    • Mechanisms of action of hydroxychloroquine and chloroquine..

    Rheumatoid Arthritis RA Rheumatoid arthritis RA is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. Chloroquine phosphate is a 4-aminoquinoline compound for oral administration. Chloroquine is an antimalarial and amoebicidal drug. The drug possesses antimalarial actions and exerts a beneficial effect in lupus erythematosus chronic discoid or systemic and acute or chronic rheumatoid arthritis. The precise mechanism of action is not known. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of.

     
  8. Aleks7974 Well-Known Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Hydroxychloroquine, the drug that could stop COVID-19 - archyde How to Know If Your Crohn’s Is Advancing Plaquenil -
     
  9. Magellan User

    Senior Care Consultant Pharmacist and President of MZ Associates, Inc. What causes seizures? Impact of Psychotropic drugs on Seizure threshold P6.311 Neurology Plaquenil - FDA prescribing information, side effects and uses
     
  10. magister46 Moderator

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