Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Can glucose and bind to chloroquine Plaquenil and quinine Hydroxychloroquine and omeprazole Hydroxychloroquine high dose Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. Plaquenil therapy and eye exams. De__0__0. I was told from the start by my rheumatologist I would have to have eye exams including visual field exams every six months due to the plaquenil therapy. My first two exams did include these tests. But my next six month appointment is coming up, and they told me I didn't need the visual field test. Plaquenil Hydroxychloroquine is a medication that is used often to treat conditions such as Rheumatoid Arthritis, Lupus Sarcoidosis, and additional autoimmune disorders. Plaquenil has been known to cause retinopathy or damage to the retina. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil eye exam how often Plaquenil/Hydroxychloroquine - which eye tests do. - LUPUS UK, Plaquenil therapy and eye exams. - Eye Care - MedHelp Hydroxychloroquine internal bleeding There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Risk of Toxicity The risk of toxicity is dependent on daily dose and duration of use. At recommended doses, the risk of toxicity up to 5 years is under 1% and up to 10 years is under 2%. Recommendations on Screening for Chloroquine and.. Plaquenil. The Risk of Retinal Toxicity with Plaquenil. My dermatologist that writes my RX for the plaquenil said I should do it every 6 months. Her husband who is my ophthalmologist says once a year is sufficient with the dose of 2 a day. My rheumy. Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Cumulative use in excess of 250 grams increases the risk for toxic retinopathy. Other risk factors include obesity, kidney or liver disease, older age. When you visit an ophthalmologist for a Plaquenil eye exam, your doctor will perform different tests to detect the presence or extent of retinal damage due to this medication. A Plaquenil screening may include a visual field test, OCT imaging, multifocal ERG, and photos of your eye.