In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Rheumatoid arthritis chloroquine Lose weight after plaquenil Hydroxychloroquine program Smoking and plaquenil Use of antimalarials ie, quinacrine, chloroquine, hydroxychloroquine HCQ can induce tissue pigmentation in a variety of organs, including skin, joint tissue, trachea, and cartilage in the nose and ears. MAIN OUTCOMES AND MEASURES The primary outcome was the clinical features of HCQ-induced pigmentation. Skin biopsies were performed on 5 patients, both in healthy skin and in the pigmented lesions. The statistical associations of HCQ-induced pigmentation with several variables were calculated using univariate and multivariate analyses. Yellow eyes and skin Get emergency help immediately if any of the following symptoms of overdose occur Symptoms of overdose. Cold, clammy skin decreased urine drowsiness dry mouth fast, weak pulse increased thirst lightheadedness, dizziness, or fainting loss of appetite muscle pain or cramps Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Chloroquine skin pigmentation Chloroquine - American Osteopathic College of Dermatology., Hydroxychloroquine-induced pigmentation in patients with. Hydroxychloroquine and skin hardeningHydroxychloroquine grade c pregnancyPlaquenil discountPlaquenil make you gain weight Changes of the skin and mucus membrane during the course of chloroquine therapy for connective tissue disorders. These female patients developed hyper pigmentation of the skin, largely on the exposed parts Hyperpigmentation of the Skin Following Chloroquine Treatment.. Chloroquine Oral Route Side Effects - Mayo Clinic. Hydroxychloroquine and skin darkening Hi All. - LUPUS UK. Skin itchiness, skin color changes, hair loss, and skin rashes. Chloroquine-induced itching is very common among black Africans 70%, but much less common in other races. It increases with age, and is so severe as to stop compliance with drug therapy. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. Skin pigmentation can be due to variety of drugs that can arise due to direct effects of the drugs as in combination with triggering factors like sun exposure. Out of several drugs some of the most common drugs that cause skin pigmentation are antimalarials drugs, tetracyclines, nonsteroidal anti-inflammatory drugs, cytotoxic drugs, amiodarone.