Flying saucer sign oct plaquenil

Discussion in 'Canadian Drug' started by Gray78, 09-Mar-2020.

  1. domodedovo Moderator

    Flying saucer sign oct plaquenil


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    In this case, the OCT demonstrates the characteristic loss of the PIL that spares the fovea, known as the flying saucer sign. Dilated fundus exam showed a large, symmetrical area of pigment dropout and mottling across the maculae and into the posterior pole, with small, crystalline deposits in this area in both eyes. Aug 06, 2014 The relative sparing of the subfoveal structures results in the characteristic “flying saucersign of advanced toxicity B.11 While much of the literature has focused on the changes to the outer retina in HCQ retinopathy, the earliest SD-OCT findings of toxicity may actually localize to the inner retina. Oct 21, 2010 All three demonstrated characteristic perifoveal outer retinal abnormalities seen on SD OCT that we have termed the “flying saucersign; these findings include preservation of the outer retinal structures in the central fovea, perifoveal loss of the photoreceptor IS/OS junction and outer retinal thinning, posterior or “sinkhole” displacement of the inner retinal structures toward the retinal pigment epithelium, 25 and variable loss of the normal foveal depression.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Flying saucer sign oct plaquenil

    Spectral domain optical coherence tomography as an effective screening., Multimodal Imaging in Plaquenil Toxicity

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  6. An electroretinogram showed bilateral absent or grossly reduced rod function and grossly reduced cone function. An OCT scan demonstrated the previously described “flying saucersign observed in patients with hydroxychloroquine-induced maculopathy.

    • Case Reports in Ophthalmological Medicine - Hindawi.
    • Spectral domain optical coherence tomography as an effective..
    • Hydroxychloroquine Plaquenil Toxicity and Recommendations..

    Jan 05, 2020 The classic "flying saucer" sign is seen on OCT and describes a preservation of the outer retinal layers subfoveally with perifoveal loss of the ellipsoid zone on both sides of the fovea in a line scan. Mild paracentral scotoma is usually the earliest clinical sign of toxicity. Presents as a subjective complaint in a perceptive patient, or on formal visual field test. There is preservation of the RPE and external limiting membrane, and downward displacement of overlying inner retinal layers, sometimes described as the flying saucer sign. In most cases, the SD-OCT findings correspond to HVF 10-2 and fundoscopic examination abnormalities 28, although in some cases SD-OCT changes may precede any other abnormality 80, 81.

     
  7. arturexp Guest

    infection, in addition to medication such as chloroquine to target the blood stages of the parasite, an additional drug, called primaquine, may also be required. CDC - Malaria - Diagnosis & Treatment United States. Glucose-6-phosphate Dehydrogenase Deficiency and Malaria. Glucose 6 Phosphate Dehydrogenase Deficiency - an overview.
     
  8. Nat15 User

    Antimalarial pharmacokinetics and treatment regimens. The quinoline antimalarials quinine, chloroquine, amodiaquine, primaquine and mefloquine comprise the majority of world antimalarial drug usage. These compounds have narrow therapeutic ratios. None of them is younger than twenty years old. The object of this article is to illustrate howthe treatmentofmalaria.

    Quinine - Wikipedia