Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil pill shape Calcium chloroquine tcr Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is relatively rare, estimated at 1 percent after five years and rising with continued therapy. 3 However. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil corneal verticillata Does Patient with Lupus Have Plaquenil Retinopathy?, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil and thyroid Cornea verticillata; Vertex keratopathy Chloroquine toxicity is characterized by whorl-like corneal epithelial deposits. Medications of the chloroquine family, including chloroquine Nivaquine. Chloroquine Toxicity, Cornea Verticillata SpringerLink. Early Plaquenil Toxicity Detected without Bull’s Eye.. Plaquenil Side Effects on Your Eyes and Vision. Introduction. The eye is an important indicator of rheumatologic disease. A wide variety of ophthalmic clinical manifestations exist including inflammation of the cornea, conjunctiva, lacrimal gland, episclera, sclera, uvea including anterior, intermediate, and posterior uveitis, and ophthalmic blood vessels. Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion Fig 12-15. A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties. Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Causes Amiodarone Fabry’s disease Chloroquine Hydroxychloroquine Indomethacin Phenothiazines etc.