Volume of distribution of chloroquine

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  1. Wertilo XenForo Moderator

    Volume of distribution of chloroquine


    Conceptual illustration of effect of drug distribution into tissue space on V: Consider 100 mg of a drug is added to 1 L of water in a beaker under two circumstances and the liquid is sampled for drug concentration (C). , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue.

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    The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data concentrations being 5 to 10 times higher. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver. It is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration. Volume of distribution may be increased by renal failure due to fluid retention and liver failure due to altered body fluid and plasma protein binding. For example, if 1000 mg of a drug is given and the subsequent plasma concentration is 10 mg/L, that 1000 mg seems to be distributed in 100 L dose/volume = concentration; 1000 mg/ x L = 10 mg/L; therefore, x= 1000 mg/10 mg/L = 100 L.

    Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. In rough terms, drugs with a high lipid solubility (non-polar drugs), low rates of ionization, or low plasma protein binding capabilities have higher volumes of distribution than drugs which are more polar, more highly ionized or exhibit high plasma protein binding in the body's environment.

    Volume of distribution of chloroquine

    Pharmacokinetics of Quinine, Chloroquine and Amodiaquine., VOLUME OF DISTRIBUTION

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  5. An analog of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively.

    • Chloroquine - Wikipedia.
    • Drug Distribution to Tissues - Clinical Pharmacology..
    • Mechanisms of action of hydroxychloroquine and chloroquine..

    This gives a C 0 = {\displaystyle C_{0}=} 100 µg/ml if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o o d {\displaystyle V_{blood}} that is V D = {\displaystyle V_{D}=} 0.08 l/kg. In our studies, a total of 431 plasma samples were prepared from 22 healthy subjects and 69 patients with vivax malaria for three different studies studies Ia, Ib, and II. In study Ia, a single dose of HCQ sulfate of 400 mg 310 mg as HCQ was administered to six healthy South Korean male volunteers and serial. Large volume of distribution 50 L/kg; Prolonged half life of several weeks 50% of chloroquine is excreted unchanged; Resuscitation Coma Prompt intubation and ventilation, if acidaemia exists, give sodium bicarbonate 1 – 2 mmol/Kg IV to prevent further toxicity during intubation. End goals should be a narrow QRS 100ms and a pH 7.45

     
  6. kim User

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Price of 3 Brands / Trade Names Medindia Generic Plaquenil Availability - Hydroxychloroquine Sulfate - DrugInformer
     
  7. Loloira User

    Plaquenil (hydroxychloroquine) is used to treat or prevent malaria, a disease caused by parasites. Methotrexate Hair Loss When and Why It Occurs and What. Can Hydroxychloroquine cause Hair Loss? Hair loss w/ plaquenil temporary adjustment or permanent?
     
  8. southcoast XenForo Moderator

    Atovaquone-Proguanil versus Chloroquine-Proguanil for Malaria. On the basis of observed trends, the proportion of subjects who took ⩾80% of prescribed doses was similar in the 2 treatment groups for the pretravel period 90% for atovaquone-proguanil recipients vs. 95% and 90% for chloroquine-proguanil recipients, respectively and during travel 98% vs. 99% and 100%.

    Malaria Prophylaxis. The ABCD of Malaria Prophylaxis. Patient
     
  9. vbirj User

    Chloroquine and HydroxyChloroquine Toxicity ROQUE Eye. In 1962, J Lawton Smith coined the term bull's eye maculopathy, regarded as the classic finding of macular toxicity. Many reports on chloroquine retinopathy exist. In contrast, only a few cases of hydroxychloroquine toxicity have been reported.

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