Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine-primaquine-phosphate tablets Plaquenil and smoking Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood. In addition, antidepressants have been associated in rare cases among the general population both non-lupus and lupus patients with worsening of feelings of depression and suicidal thoughts. This side effect is especially prevalent early in treatment, during an alteration of dosage, or in people under 25. Summary Suicidal ideation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 1 month, also take medication Lyrica, and have Fibromyalgia. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and suicidal thoughts Plaquenil Advanced Patient Information -, Antidepressants Johns Hopkins Lupus Center Taking hydroxychloroquine and sulfasalazine togetherChloroquine use in thailandPlaquenil and being in the sunTake hydroxychloroquine with neurontinPlaquenil cholesterol Jan 14, 2016 I have been taken methotrexate injections for about 10 months. I could start to see a decline in my mood but put it down to having kids and work but over the last 2 months things have for so bad I have lost a stone in a month o have constant knots in my stomach I’m never away from the toilet and I’ve been having suicidal thoughts. Methotrexate and depression - methotrexate side effects.. Will you have Suicidal ideation with Plaquenil - eHealthMe. Suicidal -. Sep 09, 2014 The results were somewhat surprising. Patients taking biologic DMARDs had the highest rates of depression, anxiety, and suicidal thoughts, while those using leflunomide showed the lowest rates. Patients using methotrexate and leflunomide reported less suicidal ideation than those using hydroxychloroquine and biological drugs 4. Find information about common, infrequent and rare side effects of Gabapentin Oral. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. depression, rare thoughts of.