I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Best malaria medication for prevention of chloroquine-resistant malaria Hydroxychloroquine sulfate painkiller Chloroquine tablet dosage for adults Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues. The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. What to expect when taking plaquenil for the first time Plaquenil hydroxychloroquine Basics, Side Effects., Taking Plaquenil for Rheumatoid Arthritis Plaquenil prasco labsPlaquenil maintenance dosage The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. To treat lupus erythematosus, the average adult dose is 400 mg once or twice daily. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Rx Side Effects New Plaquenil Guidelines and More.. How long did Plaquenil/Hydroxychloroquine take? DailyStrength. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil received an overall rating of 5 out of 10 stars from 4 reviews. See what others have said about Plaquenil, including the effectiveness, ease of use and side effects. I was frightened to take the MTX the first time since is is a chemo drug. But I bit the bullet and waited for the bad side effects. It is true I have experienced some diarrhea and nausea both of short duration but I feel like this drug is going to do me some good as long as I don’t start losing a lot of my hair, and I am encouraged.