These, as well as other commonly used medications, can cause various types of allergic reactions that frequently lead to hyperpigmentation (dark patches). There are four primary types of medication reactions that can lead to often troubling and disfiguring hyperpigmentation: A fixed drug eruption is a round, dark patch or eruption that results from a reaction to a drug (usually a prescription medication). Plaquenil altitude sickness Hydroxychloroquine normal dose Levaquin and hydroxychloroquine Hydroxychloroquine myopathy Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. A thorough history is essential to determine the cause of a pigmentary disorder. Very important information to gather during the evaluation of the patient includes the temporal relationship of medications taken and the development of the pigmentation, the presence of accentuation from exposure to sunlight, a list of medications taken, and a personal and family history of disorders such as. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. The round patch is usually fixed to one spot will appear in this same location within 24 hours of each dose taken. This type of reaction leaves a grey-blue, round patch on the skin. Hydroxychloroquine skin pigmentation Prevalence and risk factors of hyperpigmentation induced by., Drug-Induced Pigmentation Clinical Presentation History. Will my hair grow back after plaquenilPlaquenil and uctdPlaquenil and prednisone interactionPlaquenil memeCan hydroxychloroquine be taken with cholesterol-lowering medications Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Skin Pigmentation with Hydroxychloroquine Plaquenil.. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Treatment of hydroxychloroquine-induced hyperpigmentation of.. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic MAIN OUTCOMES AND MEASURES The primary outcome was the clinical features of HCQ-induced pigmentation. Skin biopsies were performed on 5 patients, both in healthy skin and in the pigmented lesions. The statistical associations of HCQ-induced pigmentation with several variables were calculated using univariate and multivariate analyses. Brown Skin Home / Skin / Pigmentation / Drug-Induced Pigmentation. Skin Drug-Induced Pigmentation. Women with brown skin, particularly those of African and Latino descent, have a high incidence of hypertension, diabetes and heart disease and consequently take medications for those medical problems.