If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Contact us if you experience any difficulty logging in. Chloroquine phosphate tablets 250 mg dosage Plaquenil ogen Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Skin pigmentation related to antimalarials is described as yellow brown to slate gray or black pigmentation, which predominates on the anterior side of the shins but can also be seen in the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. 16 This is consistent with our findings because all patients had skin. Serpentine supravenous hyperpigmentation due to hydroxychloroquine Joe F Lau1, Steven M Dean2, Thom W Rooke3 and Jeffrey W Olin4 1Northwell Health, Long Island Jewish Medical Center and North Shore University Hospital, Department of Cardiology, Hofstra Northwell School of In many cases, once the offending drug has been stopped, fading of the lesions occurs. Drug-induced skin pigmentation can become cosmetically disfiguring. Hyperpigmentation of the skin due to hydroxychloroquine Health conditions that can cause hyperpigmentation, Hydroxychloroquine-Induced Pigmentation in Patients With Systemic Lupus. Chloroquine and pregnancyWithdrawing from plaquenilPhotos of plaquenil pillsPlaquenil medication for lupus Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Hydroxychloroquine-Associated Hyperpigmentation. Serpentine supravenous hyperpigmentation due to.. Skin Pigmentation with Hydroxychloroquine. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Rare, previous reports of hyperpigmentation indicate the presence of both melanin and hemosiderin in patients being treated with antimalarial medication. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to. Skin Hyperpigmentation with Hydroxychloroquine. Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus.