One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil stopping Why chloroquine is given in liver abscess The characteristics of patients which may increase of developing toxicity symptoms while taking Plaquenil include an age of more than 60 years old, having renal or hepatic insufficiency or any existing macular degeneration and retinal disease 1. Sep 15, 2014 Symptoms. In the early stages of HCQ retinal toxicity, most of the patients could be asymptomatic. When the first symptoms start to appear their complaints are the following trouble with reading, diminished color vision, fine visual alteration due to the central or paracentral scotoma. Signs. Biomicroscopy eye exam slip lamp examination. The risk of plaquenil-induced toxic maculopathy is associated with a cumulative dose level of 1,000 grams and it usually takes 5-7 years for patients on the standard dose of 250-400 milligrams per day to reach that level. 2 Based on a dose of 200 milligrams per day for the past twenty years. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity signs and symptoms Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Retinal toxicity associated with chronic exposure to. Generic plaquenil problemsShow me a picture of hydroxychloroquine Jun 19, 2015 Brief Answer plaquenil toxicity Detailed Answer My dear, Thanks for sending your query to us. These drugs do have a toxicity but it is reason doctors are worried is that once toxicity occures,it continues even after stopping the drug. Otherthan retinal examination,useful information. What are the symptoms of Plaquenil toxicity?. Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS. Despite Plaquenil dosing recommendations, retinal toxicity.. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Signs or symptoms of cardiac compromise have appeared during acute and chronic treatment. Clinical monitoring for signs and symptoms of cardiomyopathy is advised, including use of appropriate diagnostic tools eg, ECG to monitor patients for cardiomyopathy during Plaquenil therapy. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.