Chloroquine retinopathy after drug cessation

Discussion in 'Chloroquine Pills' started by agent_orange, 28-Feb-2020.

  1. webjunk XenForo Moderator

    Chloroquine retinopathy after drug cessation


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Hydroxychloroquine and CQ retinopathy can progress even after the drugs are stopped, although the amount of progression and the risk to vision are functions of the severity of retinopathy at the time it is detected. 5,11 It seems doubtful that this late progression of damage after stopping the drug results from a continued reservoir of the drug, although clearance from the body does take many late progression may represent a gradual decompensation of cells that were injured. The potential for chloroquine phosphate and hydroxychloroquine sulfate retinopathy to progress after cessation of the drug has long been recognized, 1-4 primarily in patients with severe ring scotoma or a visible bull’s-eye lesion in the fundus. Such progression could continue for many years after the drug was stopped. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine retinopathy after drug cessation

    Retinal toxicity associated with chronic exposure to hydroxychloroquine., Progression of Hydroxychloroquine Retinopathy

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  4. Although retinal toxicity is uncommon in the large number of patients who use hydroxychloroquine worldwide and derive great benefit from the therapy, our series suggests that the prevalence of retinopathy and risk of progression despite cessation of the drug may be higher than currently thought.

    • Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine..
    • Chloroquine retinopathy - Wikipedia.
    • Common Medications That May Be Toxic to the Retina.

    Published case reports of chloroquine retinopathy rarely include details of daily dosage, but 30 reports where this information was available included 78 patients who developed impaired visual acuity an 13 had received daily doses of 250 mg or less. Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body. 2 Importance Given the infrequent occurrence of hydroxychloroquine toxic effects, few data are available about the presenting features and long-term follow-up of patients with hydroxychloroquine retinopathy, making it difficult to surmise the clinical course of patients after cessation of drug treatment.

     
  5. Petr Moderator

    Download PDF Many systemic medications may cause retinal toxicity. RCOphth guideline Hydroxychloroquine and Chloroquine. Hydroxychloroquine Retinopathy Still Alive and Well - The. Update on Screening Recommendations for Hydroxychloroquine.
     
  6. PetroviCH XenForo Moderator

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. I have an allergic reaction to chloroquine, please help? Chloroquine Oral Uses, Side Effects, Interactions, Pictures. Teva-Chloroquine - Rexall
     
  7. Samber Guest

    Melanoma - Symptoms and causes - Mayo Clinic Acral-lentiginous melanoma is a rare form of melanoma that can occur under a fingernail or toenail. It can also be found on the palms of the hands or the soles of the feet. It's more common in black people and in other people with darker skin pigment. Melanoma in the mouth, digestive tract, urinary tract or vagina.

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  8. hsw XenForo Moderator

    Chloroquine Oral Route Proper Use - Mayo Clinic If you are also taking kaolin or antacids, take them at least 4 hours before or after using chloroquine. If you are also taking ampicillin, take it at least 2 hours before or after using this medicine. Dosing. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.

    Chloroquine therapy in patients with recent-onset rheumatoid.