Indeed, the ability to salvage nucleotides from sources within the body alleviates any significant nutritional requirement for nucleotides, thus the purine and pyrimidine bases are not required in the diet. The salvage pathways are a major source of nucleotides for synthesis of DNA, RNA and enzyme co-factors. Ara hydroxychloroquine Percentage of people with hair loss on plaquenil Plaquenil toxicity eye Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and. The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium berghei. Biochem Pharmacol. PARKER FS, IRVIN JL. The interaction of chloroquine with nucleic acids and nucleoproteins. J Biol Chem. 1952 Dec; 199 Download Citation Differential effects of chloroquine on cardiolipin biosynthesis in hepatocytes and H9c2 cardiac cells Chloroquine is a potent lysomotropic therapeutic agent used in the. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Following their synthesis in the liver the nucleotides are dephosphorylated and in part phosphorolytically cleaved into nucleobases and ribose-1-phosphate for transport to the blood and then subsequent uptake by cells of the other organs. Within the body the major site of de novo nucleotide synthesis, for the replenishment and maintenace of intracellular pools, is the liver. Chloroquine nuclei acid biosynthesis Nucleic acids article Khan Academy, Differential effects of chloroquine on cardiolipin. Plaquenil and optic neuropathyChloroquine cos-7 Uric acid excretion and reabsorption occurs within the proximal tubules of the kidney. Elevation in uric acid levels can result in precipitation of urate crystals with monosodium urate crystals being the most commonly occurring in the synovial fluids of the joints. Pathways for the catabolism of the purine nucleotides. Nucleotide Metabolism Nucleic Acid Synthesis and Catabolism. Chloroquine - Wikipedia. Plasmodium falciparum Nucleic acid and pigment changes in.. The extent of inhibition increased with drug concen- tration and was almost complete 9S" with 10 mM chloroquine Table 3. DISCI SSION The results demonstrate that millimolar concen- trations of chloroquine strongly reduce biosynthesis of nucleic acids and proteins in the retina. IMP, whose de novo biosynthesis we have just seen, is not a normal constituent of nucleic acids; it will be converted into adenylic and guanylic nucleotides, which are the major purine nucleotides found in ribonucleic and deoxyribonucleic acids. These transformations are diagrammatically depicted in figure 6-21. Artificial nucleic acid analogues have been designed and synthesized by chemists, and include peptide nucleic acid, morpholino- and locked nucleic acid, glycol nucleic acid, and threose nucleic acid. Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecules.