Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people. Chloroquine acidity Hydroxychloroquine 200 mg coupons Chloroquine is used extensively in malaria endemic areas in Africa to treat the uncomplicated form of Plasmodium falciparum malaria. However, the efficiency of chloroquine has been severely impacted by the recent development of chloroquine resistant plasmodium falciparum parasites. The development of chloroquine resistance by malaria parasites is increasing at an alarming rate especially in the tropical countries where it is used extensively as an antimalarial drug 2. FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of. This is because the majority of infections in Africa are caused by Plasmodium falciparum, the most dangerous of the four human malaria parasites. It is also because the most effective malaria vector – the mosquito. Anopheles gambiae– is the most widespread in Africa and the most difficult to control. These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug. Chloroquine-resistant malaria is now widespread in africa Malaria - Wikipedia, Chloroquine-Resistant Falciparum Malaria From Africa. P falciparum resistance to chloroquineDrug quinine and chloroquine Chloroquine was the most common anti-malarial used according to surveys from 14 of 21 countries analysed, predominantly in West Africa. SP was most commonly reported in two of 21 countries. Patterns of chloroquine use and resistance. - Malaria Journal. The burden of malaria in Africa. Chloroquine-Resistant Malaria definition of Chloroquine.. The forest zone of West Africa has a high risk of falciparum malaria throughout the year. Chloroquine-resistant parasites are widespread but their distribution is still patchy. While chloroquine-resistant malaria was rapidly outcompeted after the removal of chloroquine as the first-line treatment in Malawi, a similar return of chloroquine-susceptible infections has not been observed in Asia. The uniqueness of this phenomenon in Africa, but not in Asia, is likely multi-factorial. FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of limited value.