Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil make nails brittle Can i just stop taking hydroxychloroquine Plaquenil tests Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. BTW, a great resource for medication questions is your Pharmacist. If you look up the "half life" of Plaquenil on the internet, you will find it does stay in your system for quite a while, as long as 2-3 months. Of course, its concentration decreases every day. If you look up the "half life" of Plaquenil on the internet, you will find it does stay in your system for quite a while, as long as 2-3 months. Of course, its concentration decreases every day. I was a lucky person while taking it. no negative side effects. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. How long does it take for plaquenil to kick in How long does it take for plaquenil hydroxychloroquine to., How long does it take for plaquenil to leave your system. Plaquenil and fluWhat is another name for hydroxychloroquine From my point of view I have had less pain in my legs at night and the fatigue isn’t as bad. My rash is now coming and going rather than staying. But it is t perfect yet and may never be but inflammation specifically if experienced for a long period of time changes how cells behave and this can take a long time to reverse and may never fully. Plaquenil - time to kick in? rheumatoid. How long does it take for plaquenil to leave your system? Page 2. Plaquenil - How long to take effect?. Rheumatoid Arthritis - how long will it take for hydroxychloroquine to set in & help with the pain? Asked by Diane E Updated 24 March 2011 Topics She said we could try Plaquenil - a milder drug. I was told it takes two months before patients feel any improvement, it took little less for the drug to kick in. Now, it's been a year - I have no flares, no pain and no side effects I can think of. I take one pill in the morning, one in the evening. This drug works well for me." Hi everyone, I was just wondering how long it took for Plaquenil to start working for you? I've been on it for about a month now, and it hasn't worked for me yet, but I know that it can take up to 4 months to kick in.