I couldn't tolerate the generic, but the brand name has a coating for the stomach. Wallace's book and found the stats, plus my rheumie telling me much the same, that many people with lupus (something like 40% or more) "present" with GI problems. Meaning long enough to start to sort out whether your problems were mainly from the disease or from the med? How long for plaquenil to work What is plaquenil used for in lupus I originally took Plaquenil Sanofi but this brand is now discontinued. The generic form of this, on my prescription, gives me serious digestion and stomach upsets to a point I spent months trying to figure out what I thought was irritable bowel syndrome. Has anyone found a good alternative UK brand that doesn't create this side affect. I "know" I need some meds, but cannot tolerate Plaquenil. Wondering if anyone has come across something "natural" that mimics it. Thanks & LIGHT*****carole - Hi, Carole. When I started Plaquenil, my GI system was in an uproar. But it usually was anyway. I didn't realize, until I saw Dr. Is there a drug that I can. Is there a drug that I can take to replace plaquenil? Asked by tanner01. please don't think that you did not help,because you did. whoever takes the time to stop and answer my question to the best of their ability is a help. you never know if what you say gives that person one more step closer to her. Although I take Enbrel, and MTX, neither one work as well as the Plaquenil and the fatigue and joint pain have returned full force. I had to get off of plaquenil as well b/c of toxicity and benign tumors behind my eyes. Hi there, I normally post on the arthritis board, and due to toxicity of the Plaquenil after 2 years, I have had to discontinue it, since I failed the visual field testing. I'm sure you do feel like you're losing your mind.(((hugs)))Pat Hi there, I had put a posting about this a few weeks ago on here. Best alternative to plaquenil Lupus Treatment Options Lupus Medications - Kaleidoscope., Natural" alternative to Plaquenil. - HealthBoards Methotrexate vs plaquenil for raPlaquenil and folic acidPlaquenil aravaWhere can i buy plaquenil without a prescriptionEye test for plaquenil toxicity Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. Taking Plaquenil for Rheumatoid Arthritis. Is there a drug that I can take to replace plaquenil?. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.