Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil retinopathy info for patient Hydroxychloroquine sulfate 200 mg dosage Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. When I started Plaquenil back in November last year, I had terrible headaches which started about 1/2 an hour after taking pills. It happened so consistently that I started taking tylenol when I would take it. I would lay down with an ice pack under my neck and darken the room. After about 30min of resting with the ice pack. Plaquenil hydroxychloroquine "I’ve been on plaquenil 400mg once a day for 6 months now due to Sjogrens. If your are wondering how long the plaquenil takes to work, it took about 3 months before I starting feeling better. Now at 6 months I’m noticing more symptoms. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil less headaches Plaquenil Side Effects Common, Severe, Long Term -, Plaquenil and headaches DailyStrength Cost of aralenChloroquine toxicity octPlaquenil medicines.ieFacts on chloroquine PLAQUENIL is useful in patients with the following disorders who have not responded satisfactorily to drugs with less potential for serious side effects lupus erythematosus chronic discoid and systemic and acute or chronic rheumatoid arthritis. PLAQUENIL®. Hydroxychloroquine User Reviews for Sjogren's. -. Plaquenil hydroxychloroquine Basics, Side Effects & Reviews.. A lot of people have less than 4, or as in my case, more than 4 but spread out over much more than 5 years. So it's very possible for plaquenil to do good without you being considered to have Lupus. I went on plaquenil in 2004 for joint pain, high ANA and pericarditis. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus.