It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Is plaquenil good for osteoarthritis Effects of plaquenil on teeth Chloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria and to prevent malaria in areas or regions where chloroquine is known not to work resistance. An Overview of Chloroquine Interactions Chloroquine phosphate Aralen ® is a prescription medication licensed to prevent and to treat malaria infections. It is also used to treat a parasite infection called amebiasis. Chloroquine may react with many other medications. The interaction evaluation shows that chloroquine has significant effects on primaquine pharmacokinetics, whereas primaquine has negligible effects on the disposition of chloroquine. Coadministration of chloroquine increased peak primaquine concentrations by approximately 63% and overall primaquine exposure by 24%. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Chloroquine interactions , Drug Interactions With Chloroquine - Malaria Home Page Plaquenil weight lossHydroxychloroquine and sun exposure Hydroxychloroquine may also be subject to the known interactions of chloroquine even though specific reports have not appeared. Ampicillin Chloroquine significantly reduced the bioavailability of ampicillin. An interval of at least two hours between intake of this agent and chloroquine should be observed. Chloroquine - Mechanism, Indication, Contraindications.. Pharmacokinetic Interactions between Primaquine and Chloroquine. Chloroquine Oral Uses, Side Effects, Interactions, Pictures, Warnings.. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best.