Chloroquine and filipin lysosome

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  1. Mc_Leod XenForo Moderator

    Chloroquine and filipin lysosome


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    Primaquine and chloroquine Hydroxychloroquine immunosuppressant

    The unprotonated form of chloroquine preferentially accumulates in lysosomes as it rapidly diffuses across cell/organelle membranes. Once in the lower pH 4.6, environment of the lysosome chloroquine becomes protonated and can no longer freely diffuse out. We found that apoptosis generated by TRAIL, the cognate ligand for DR5, remained unchanged upon chloroquine lysosomal interference, indicating that 5-FU activates the receptor by a discrete mechanism. In support, depletion of membrane cholesterol or hampering cholesterol transport drastically reduced 5-FU cytotoxicity. Lysosomes are essential for the degradation of old organelles and engulfed microbes and also play a role in programmed cell death 1. Lysosomotropic agents e.g. chloroquine, accumulate preferentially in the lysosomes of cells in the body. These agents tend to have both lipophilic or amphiphilic compounds with basic moieties.

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    Chloroquine and filipin lysosome

    Targeting endosomal acidification by chloroquine analogs as a., Aberrant DR5 transport through disruption of lysosomal.

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  5. Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugsContinue reading Chloroquine & Hydroxychloroquine.

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    Chloroquine is a weak base that accumulates in acid spaces and dissipates pH L. High concentrations of chloroquine are toxic resulting in cell death. Indeed, cells from patients with MLIV are highly sensitive to chloroquine, consistent with more acidic pH L in these cells. However, with the aim of testing the potential use of chloroquine for treatment of MLIV, we tested whether chloroquine can also reverse the MLIV phenotype. Although the precise mechanism underlying the antimalarial effects of chloroquine remains unknown, chloroquine seems to exert its effects through the weak-base lysosome-tropic feature. When chloroquine enters the lysosome, it becomes protonated because of the low pH within the lysosome, and accumulation of the protonated form of chloroquine. Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line.

     
  6. amoskowcity Well-Known Member

    Most birth defects are present within the first three months of pregnancy, when the organs are still forming. The mother or father may pass on genetic abnormalities to their baby. Hydroxychloroquine Use During Pregnancy Antiphospholipid Syndrome and Potential New Treatments HSS The Effects of Immunosuppressive and Anti-inflammatory.
     
  7. Eugene2008 Guest

    Malaria Flashcards Quizlet Malaria can be treated effectively early in the course of the disease but that delay of appropriate therapy can have serious or even fatal consequences Travelers who have symptoms of malaria should be advised to seek prompt medical evaluation, including obtaining blood smears, as soon as possible

    Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC
     
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