According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. Plaquenil cause depression Chloroquine is a painless suicide Plaquenil pulmonary sarcoidosis No atovaquone-proguanil recipients discontinued treatment because of an adverse event, whereas 2 chloroquine-proguanil recipients discontinued the regimen during the posttravel period because of drug-related gastrointestinal events mild-to-moderate nausea, abdominal pain, and diarrhea in one subject and severe nausea with mild abdominal pain in the other. Chloroquine is used to treat and to prevent malaria. Chloroquine is also used to treat amebiasis infection caused by amoebae. Chloroquine may also be used for purposes not listed in this medication guide. Chloroquine. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. Atovaquone- introduced in 1996- 1st case of resistance 1996. from "Global defence against the infectious disease threat" World Health Organization, 2003. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Chloroquine atovaquone Proguanil C11H16ClN5 - PubChem, Chloroquine Uses, Side Effects & Warnings - Plaquenil helps spasmsPlaquenil and cirrhosis This medication contains 2 medicines atovaquone and proguanil. It is used to prevent and treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter. Atovaquone-Proguanil Oral Uses, Side Effects, Interactions.. History of antimalarials Medicines for Malaria Venture. Aralen chloroquine Malaria Drug Side Effects & Dosage. Chloroquine or multidrug-resistant falciparum malaria. Atovaquone plus proguanil combination preparation. 250 mg atovaquone plus 100 mg proguanil. 4 tablets as a single dose on each of three consecutive days. Chloroquine or multidrug-resistant falciparum malaria. Quinine plus doxycycline. 300 mg quinine 100 mg doxycycline. Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons. A tablet containing a fixed dose of 250 mg of atovaquone and 100 mg of proguanil hydrochloride, taken orally, has been highly effective and safe in a 3-day regimen for treating mild to moderate attacks of chloroquine- and multidrug-resistant falciparum malaria.