I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. When plaquenil doesn t work Hydroxychloroquine creatinine Lupus Support Group Lupus is an auto-immune disease in which the immune system cannot distinguish between threats like viruses and bacteria, and healthy cells and tissue. As a result, the body produces antibodies that inflict cell damage, most commonly targeting joints, skin, kidneys and the nervous system. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Plaquenil is an arthritis medication and an anti infectious agent. Prednisone is a steroid. There may be a negative interaction between Plaquenil and alcohol. There may be a negative interaction between Prednisone and alcohol. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Lupus plaquenil prednisone Plaquenil User Reviews for Systemic Lupus. -, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center Hydroxychloroquine for lupus side effectsHydroxychloroquine mfg by mylan Plaquenil - Better Than Prednisone? The conclusion is that I have an autoimmune disease that has affected my kidneys. Throughout the 12 1/2 years, I have been prescribed 10mg of predinsone a day during my `worst' time to 1 mg every other day when I was in `serious' remission. Immune & Autoimmune - Lupus Plaquenil - Better Than Prednisone?. Compare Plaquenil vs Prednisone - Comprehensive Analysis by.. Lupus Medications and Treatments. When I was first diagnosed with lupus I was put on prednisone and plaquenil to help control my severe joint inflammation. The prednisone began workiing in 3 days and helped reduce my joint inflammation. I had some issues with the plaquenil, nausea and extremity swelling. Backstory I was diagnosed with SLE 2 years ago, my rheumatologist prescribed plaquenil but this past month my diagnosis had changed to lupus nephritis stage 3. I was referred for a nephrologist who prescribed prednisone. I asked if I should take just the prednisone but he said I should stay on both. Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow.