Plaquenil macular toxicity

Discussion in 'Plaquenil' started by Sev, 10-Mar-2020.

  1. chasovoj Moderator

    Plaquenil macular toxicity

    Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating.

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    There was a dose response, such that those receiving doses greater that 5 mg / kg had the greatest risk of retinal toxicity. Risk factors for retinopathy included higher doses and longer durations of use. Other major factors are concomitant renal disease, use of tamoxifen and prior retinal or macular disease. Plaquenil Toxicity Plaquenil hydroxychloroquine is a medicine commonly used to treat patients with systemic lupus erythematosus and rheumatoid arthritis. After prolonged use, it can sometimes damage the macula and cause central vision loss. Risk factors for toxicity. Reported risk factors for toxicity include daily dose 400 mg, or 6.5 mg/kg ideal/lean body weight for short individuals; cumulative dose 1000 g; duration of use 5 years; renal or hepatic dysfunction; obesity; age 60 years; and pre-existing retinal disease or maculopathy 31.

    Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area).

    Plaquenil macular toxicity

    Retinal toxicity associated with chronic exposure to., Plaquenil Toxicity - Bennett & Bloom Eye Centers

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  4. Symptoms of Plaquenil toxicity are similar to other macular problems and may include Decreased fine vision or difficulty reading. Changes in Color vision. Missing Spots or shadows near the center of the vision.

    • Plaquenil Toxicity Screening - Retina Group of New York.
    • Hydroxychloroquine-related retinal toxicity Rheumatology..
    • Has anyone experienced plaquenil toxicity with damage to eyes?.

    Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. The risk of developing retinal toxicity is less than 2% in patients who use dosages below the recommended threshold for up to 10 years. The risk increases significantly after 20 years of therapy. Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss.

  5. Pummer Well-Known Member

    Several things can lead to extra fluid, or edema, in one leg, or both: Congestive heart failure: This happens when your heart is too weak to pump all the blood your body needs. Taking Plaquenil for Rheumatoid Arthritis Plaquenil Hydroxychloroquine - Side Effects, Dosage. How to Avoid Having Heavy Legs & Swelling of Ankles.
  6. ppch XenForo Moderator

    Malaria Prevention – Travel to Areas with Chloroquine-Resistant Malaria. For destinations where chloroquine-resistant malaria is present, in addition to mosquito avoidance measures, chemoprophylaxis options are limited to atovaquone/proguanil, doxycycline, and mefloquine. Travel to Areas with Mefloquine-Resistant Malaria

    Recommended Malaria Prophylaxis for Travelers
  7. Domdruzei XenForo Moderator

    Started on Plaquenil Although Blood Work was Negative. I was diagnosed with UCTD and my rheumatologist put me on 200mg of Plaquenil twice a day -- I also have osteoarthritis in one hip. She told me that the Plaquenil could take up to 6 months to work but I noticed a change at about the 10 week mark.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More