Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Malaria chemoprophylaxis chloroquine phosphate tablet 500 mg Plaquenil and heartburn Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. It's not safe to take Ibuprofen while on Prednisone. Taking Ibuprofen together with Prednisone may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding. You can take Advil or another NSAID while taking Plaquenil hydroxychloroquine as long as NSAID isn't contraindicated for you. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Can you take prednisone with hydroxychloroquine Plaquenil vs Prednisone Comparison -, Can you take hydroxychloroquine with antihistamine - Answers Plaquenil withdrawal headacheHome remedies plaquenil hyperpigmentation There could be many reasons why you were put back on Prednisone. Plaquenil is a great drug I have no experience with it, but many people with lupus take it. Both pred and plaq are often prescribed together. I'd ask your rheumy about it and have them explain why they made that choice for you. Good luck! Ginny Prednisone/Plaquenil question -. Prednisone and Plaquenil DailyStrength. Prednisone and Hydroxychloroquine sulfate drug.. I have RA and am presently being treated with Prednisone5mgand Plaquenil. Wondering if it is ok to take Hep A and B vaccines while on these meds. Answer. Yes. Both vaccines are safe with your current medications. The flu shot and pneumonia vaccine are also safe. Stop taking this medicine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Before using hydroxychloroquine, tell your doctor if you are allergic to any drugs, or if you have psoriasis, porphyria, liver disease, alcoholism. Jessie, plaquenil can take up to 6 months to take effect. I was told to not not try to discontinue any of my lupus meds while my medical condition was unstable. At the time, I had a sinus infection. Jessie, 3 years ago, my doctor discontinued my plaquenil ie. hydroxychloroquen and substituted it for an older anti-malerial drug named "chloroquin".