Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Hydroxychloroquine and anxiety Plaquenil cross eyes Chloroquine phosphate fish Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Methotrexate and High Blood Sugar Readings. In those who do not have diabetes, the use of methotrexate can precipitate type 2 diabetes. One of the main symptoms of diabetes is a high blood sugar reading upon waking or a high A1C or average blood sugar value. So while Plaquenil may lower blood sugar it’s not in a controlled way and considered a negative side effect, even if you have high blood sugar readings in the first place. You need to particularly alert if you are adding plaquenil to anti-diabetic medications as your blood sugar level could bottom out dangerously. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil and high blood sugar Plaquenil Hydroxychloroquine Sulfate - Sanofi, Methotrexate and High Blood Sugar Readings Long-term effects of taking plaquenil In this context, those patients with fasting blood sugar level 100–125 mg/dL or hemoglobin A1c 5.7–6.5% were included in the study. All patients were physically examined by the physician and anthropometric parameters such as weight, height, body mass index and waist circumference were measured. The effect of hydroxychloroquine on glucose control and.. Lupus & Type II Diabetes - General Discussion - Life With Lupus. Existing arthritis drug might help fight diabetes. When you think about RA, the term "blood sugar" might not come to mind. But the disease can affect your body in surprising ways. How Rheumatoid Arthritis Can Affect Your Blood Sugar Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. I did suffer low blood sugar when coming of dexamethasone and am prone to it, I am not diabetic, although my Mum was but I am not - if anything my sugar levels are lo rather than high but it is noticeable now I am on the Plaquenil, I guess I just have to adapt around it and eat little and often but the weight loss, well I am 12 stone and need.