Keflex is a broad-spectrum cephalosporin antibiotic used to treat upper respiratory infections, urinary tract infections, as well as ear, bone, and skin infections. This antibiotic exhibits bactericidal properties by interfering with formation of the cell wall, causing osmotic imbalance and ultimately cell lysis. Sulfa drugs, also known as sulfonamides, are chemical compounds that contain a SO2NH2 moiety. Based on their chemical structure, these drugs are divided into three classes, however, they all have the same mechanism of action. These drugs inhibit bacterial growth by acting as a competitive inhibitor to the enzyme, p-aminobenzoic acid. PABA is required for the biosynthesis of folic acid, which in turn is required for the synthesis of nucleic acids, and ultimately, DNA and RNA. Bacterial organisms sensitive to sulfa drugs are unable to synthesize folic acid in the presence of these antibiotics, and thus are unable to synthesize the compounds necessary for cellular growth and multiplication. metoprolol iv to po conversion The buildup of thick, sticky mucus in the lungs makes people with cystic fibrosis more likely to develop bacterial infections that can last for short periods of time (known as acute infections or exacerbations) or for many years. The good news is that many of these infections can be treated. To keep them in check, antibiotics are taken by people with CF as part of regular daily treatment. For lung exacerbations, people with CF may receive intravenous (IV) -- that is, directly into the veins -- antibiotics in addition to the inhaled or oral antibiotics. See how inhaled antibiotics work to help control bacteria in your lungs. Inhaled antibiotics should be taken last, after bronchodilators (if you take them), mucus thinners, and airway clearance techniques, so your lungs will be as clear of mucus as possible. This allows the antibiotics to reach deep into your lungs to treat the bacteria that cause infection. Azithromycin versus amoxicillin Acute Exacerbations of Chronic Bronchitis in Adults The usual adult dosage in the treatment of acute exacerbations of chronic bronchitis is 1 Sulfamethoxazole and Trimethoprim Double Strength tablet, USP, or 2 sulfamethoxazole and trimethoprim single strength tablets, USP, every 12 hours for 14 days. sertraline constipation Feb 16, 2018. Bactrim is a combination of sulfamethoxazole, an anti-bacterial sulfonamide a "sulfa" drug, and trimethoprim, a folic acid inhibitor. Cipro is a. INTRODUCTION. Trimethoprim-sulfamethoxazole TMP-SMX, also known as co-trimoxazole, is a combination of two antimicrobial agents that act synergistically against a wide variety of bacteria. Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. hence medications containing sulfonamides are prescribed carefully. It is important to make a distinction between sulfa drugs and other sulfur-containing drugs and additives, such as sulfates and sulfites, which are chemically unrelated to the sulfonamide group, and do not cause the same hypersensitivity reactions seen in the sulfonamides. Nowadays, while sulfonamides seldom appear in the prescriptions written by doctors in developed countries, sulfonamides are still common antimicrobial medications in developing countries owing to their low price. Although there has been no specific study to oppose their combined use, there is no practical reason and need for taking these 2 sets of both together. In some cases, the routine antibiotic is suspended until the other one is completed. So, take one only based on clinical judgment with or without urine culture for specific selection with a timely follow-up. In short, please clarify with your prescribing physician. Read more See 1 more doctor answer I cannot think of any condition that would require taking Cipro (ciprofloxacin) and Flagyl indefinately except for a polymicrobial infection of a foreign body that was impossible to remove. Read more on different std's and the std's taht one treats (trichomonas, and non-specific vaginosis) the other one doesn't (doxycycline works on most chlamydia and gonorrhea but not the other ones). Read more There are several infections that might require treatment with both drugs, and taking only one of them could be dangerous. Sometimes we are on a medication routinely (ie- Doxycycline for acne) and a different antibiotic becomes necessary for another reason. Your doctor wouldn't have prescribed both of them without good reason. If you need more information about the reasons, contact the doctor's office. Read more Drug-drug interaction: Bactrim (sulfamethoxazole and trimethoprim) delays the hepatic metabolism of coumadin, thereby prolonging the inr/protime and bleeding risks. Read more See 1 more doctor answer Yes but why do you need to take these 2 drugs? Nitrofurantoin is a urinary antiseptic that does not achieve adequate tissue levels to treat an invasive infection. Read more However would need to know more about the infection you are under treatment to know if this is a reasonable combination! It has many severe potential toxicities including nausia and vomitting that occur in 17-39%, severe lung reactions, hepatitis, hemolytic anemia and peripheral neuropathy. I see no problem though unless you are allergic to sulfa containing drugs, or metronidazole ... Is ciprofloxacin sulfa based Sulfa allergy Which medications should I avoid? - Mayo Clinic, Bactrim sulfamethoxazole & trimethoprim vs. Cipro ciprofloxacin What is xanax used for Xanax wiki Oral 15 to 20 mg/kg/day based on the trimethoprim component orally daily in 4 equally divided doses every 6 hours for 14 to 21 days IV 15 to 20 mg/kg/day based on the trimethoprim component IV daily in 3 or 4 equally divided doses every 6 to 8 hours for up to 14 days. Sulfamethoxazole / Trimethoprim Dosage Guide with. UpToDate Bactrim vs. Cipro Side Effects & Differences - RxList Dec 22, 2017. Sulfa allergies are an uncommon reaction to some medications. sulfonamide antibiotics, including sulfamethoxazole-trimethoprim Bactrim. where can i purchase erythromycin Helpful, trusted answers from doctors Dr. Mumneh on sulfa based antibiotics list It sounds like it may be safer not to use antibiotics. A steroid spray with a course of Prednisone may help. Even gentle saline spray may be useful. Talk to your doctor about your allergies and testing to confirm them. All the best. Nov 12, 2018. Sulfa ciprofloxacin, side-effects, called sulfonamides, high quality. contain sulfa drugs combined with an alternative, sulfa based anti biotics.