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Tamoxifen vs ovary removal

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  1. alvis Well-Known Member

    Tamoxifen vs ovary removal

    The following recent guidelines address oophorectomy, and other methods of endocrine therapy/ovarian suppression, in breast cancer patients: European Society for Medical Oncology. Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (Aebi). 2011 “Patients with tumors considered of high or uncertain responsiveness (estrogen receptor (ER) ≥1%) should be treated with endocrine therapy. In premenopausal patients tamoxifen alone (20 mg daily for 5 years) or the combination of ovarian function suppression with tamoxifen are standard therapies in particular after chemotherapy; ovarian function suppression and tamoxifen is at least as effective as chemotherapy without further hormonal therapy. Longer term therapy may be effective in patients with node-positive disease. Ovarian function ablation may be achieved by bilateral oophorectomy which leads to irreversible ablation of ovarian function. Gonadotropin-releasing hormone analogs (Gn RHAs) lead to reversible ovarian suppression sufficient for therapeutic activity. nolvadex generic Dear Onco Link "Ask The Experts,"One year ago, I was diagnosed with DCIS. The tumor was excised successfully with free margins but the words "microinvasive" were used. To be on the safe side, my surgeon performed an axillary node dissection and all nodes were negative. I received 25 radiation treatments and was prescribed Tamoxifen. The Tamoxifen caused severe bleeding to the point that I recently underwent a total hysterectomy. My question: I'm confused about the fact that since I no longer have ovaries to produce estrogen, how does the Tamoxifen help me? Thank you for this Internet site; it has been the most informative site. Kevin Fox, MD, Assistant Director, Clinical Affairs and Associate Professor of Hematology/Oncology at the Abramson Cancer Center of the University of Pennsylvania, responds: Tamoxifen doesn't "need" ovaries present producing estrogen to be valuable.

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    Sep 9, 2016. A 2008 study shows that premenopausal women who had their ovaries removed and took tamoxifen for 5 years after breast cancer surgery had. cialis incontinence Feb 2, 2018. Ovarian suppression can be permanent surgery or temporary. 5 years of breast cancer compared to 15% receiving tamoxifen therapy only. Jun 4, 2018. TEXT Tamoxifen and Exemestane Trial and SOFT Suppression of Ovarian Function Trial, randomized nearly 6,000 premenopausal women.

    Ovarian suppression is the term used to describe treatments that stop the ovaries from making oestrogen, either permanently or temporarily. You might hear different terms for ovarian suppression such as ovarian function suppression and ovarian ablation. Ovarian suppression is used: Some breast cancers are stimulated by the hormone oestrogen. This means that oestrogen in the body helps the cancer to grow. This type of breast cancer is called oestrogen receptor positive (ER ). Invasive breast cancers are tested to see if they are ER using tissue from a biopsy or after surgery. Before the menopause, oestrogen is mainly produced by the ovaries. Patients whose breast cancer is fueled by the hormones estrogen or progesterone are often treated with therapies that cut off or reduce the body’s supply of these hormones. This can be accomplished by surgery to remove the ovaries, which produce estrogen and progesterone, or through drugs such as Lupron or Zoladex, which shut down estrogen and progesterone production in the ovaries. Ovarian suppression is an option only for women who have yet to enter menopause. Postmenopausal women naturally have much lower levels of circulating estrogen and progesterone, because their ovaries make much less of the hormones. (Menopause doesn’t cause estrogen levels to drop to zero because fat cells still produce small amounts of it.)Cutting estrogen levels causes menstrual periods to stop. If drugs are used to suppress ovary function, menstrual periods may resume when the drug therapy is stopped. For patients who undergo ovary-removal surgery, however, the procedure leads to early menopause.

    Tamoxifen vs ovary removal

    Tamoxifen or ovary removal? - Sunshine777's Question - Cancer., Ovarian Suppression Therapy for Young, Pre-Menopausal Women.

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  3. Aug 26, 2016. I now think I imagined the conversation that said removal of ovaries would. next week to discuss ovary removal or hysterectomy vs zoladex.

    • Removal of Ovaries vs. Tamoxifen - Breast Cancer Care Forum - 1007764
    • AI plus ovarian suppression yields benefit in high-risk younger breast.
    • Ovarian Suppression Therapies for Breast Cancer Treatment Susan.

    Mar 3, 2002. My question I'm confused about the fact that since I no longer have ovaries to produce estrogen, how does the Tamoxifen help me? Is there. where to buy generic viagra online forum If the ovaries are removed, or if they are stopped from working, there's less. hormone therapy such as tamoxifen or drugs known as aromatase inhibitors. Nov 10, 2017. A recently published model of the benefits of ovarian ablation. by this huge longitudinal study, sought to ask whether removing the ovaries at the. effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5.

  4. K.B New Member

    In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This sheet talks about whether exposure to sertraline may increase the risk for birth defects over that background risk. This information should not take the place of medical care and advice from your health care provider. Sertraline is a medication that has been used to treat depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (a severe form of premenstrual syndrome), and social phobia. Sertraline belongs to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). While everyone breaks down medication at a different rate, on average sertraline has a half-life (time it takes to eliminate one half of the drug from the body) of 26 hours. Most of the drug will be out of your system 6 days after stopping sertraline. You should always discuss any changes in your dose or stopping your dose of sertraline with your health care provider. In particular, since some people have withdrawal symptoms when they suddenly stop taking sertraline, your health care provider may suggest that you gradually decrease the dosage that you are taking before you completely stop taking the medication. Sertraline Zoloft® MotherToBaby decadron to prednisone Sertraline - Wikipedia Sertraline uses & side-effects PatientsLikeMe
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