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    Amanda Lautieri is a Senior Content Editor at American Addiction Centers. She has more than 10 years of professional editing experience that includes working as a web editor for several major online publishers and editing medical content ranging from academic texts to online training and re-certification courses for emergency medical service responders. Benzodiazepines are a class of prescription drugs with sedating properties that stem from their ability to increase the activity of the inhibitory neurotransmitter known as GABA. One of the most popular of these medications is Xanax, or alprazolam in its generic form, as reports that in 2011, it was the 11th most prescribed drug in the United States. Xanax is used in the management of panic and anxiety disorders. Food and Drug Administration (FDA) prescribing information for Xanax indicates that taking the drug can lead to dependence, especially when taking high doses for longer than a month. Xanax is commonly abused because, in addition to its sedative effects, its use is associated with increased dopamine release in the reward pathways of our brains. GABA acts as a kind of natural sedative in the brain, slowing down certain functions and muting reactions to stress. In 2011, the Drug Abuse Warning Network (DAWN) reported that close to 10 percent of all emergency department visits related to the abuse of pharmaceuticals involved the benzodiazepine, or benzo, alprazolam. Over time, Xanax may actually influence the production of GABA, and the brain may stop making it without the presence of the drug. WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS XANAX is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma, and death. Do not take XANAX if you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in XANAX. Do not take XANAX if you are currently taking antifungal treatments including ketoconazole or itraconazole. XANAX is a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep XANAX in a safe place to prevent misuse and abuse. XANAX can make you sleepy or dizzy, and can slow your thinking and motor skills.

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