Most doctors who prescribe anti-depressants for benzodiazepine withdrawal, or for any other purpose, will prescribe one of the modern classes of SSRIs (Selective Serotonin Reuptake Inhibitors) that includes Prozac, Paxil, Zoloft, Celexa, and Serzone. Or they sometimes prescribe one of two even more recently developed drugs: Effexor and Wellbutrin. Doctors often prescribe these particular drugs because, in addition to their anti-depressant properties, they are recognized as anxiolytics (anti-anxiety agents). Ironically, all of these drugs are known to heighten anxiety and agitation, though this side effect often diminishes after the first few weeks of use. Even the SSRIs such as Paxil and Zoloft which are thought to have a primary sedative effect often cause heightened anxiety when you are in withdrawal. This heightened anxiety may be one reason that people in benzodiazepine withdrawal often discontinue the use of these drugs after a short period of time. 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Zoloft (sertraline) is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Zoloft may also be used for purposes not listed in this medication guide. You should not use Zoloft if you also take pimozide, or if you are being treated with methylene blue injection. Do not use Zoloft if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. Some young people have thoughts about suicide when first taking an antidepressant. Report any new or worsening symptoms to your doctor. Question: What can cause a false-positive urine drug screening for benzodiazepines? Answer: First introduced in the 1960s, benzodiazepines fall under the class of drugs referred to as sedative-hypnotics. It is not uncommon, however, for physicians to prescribe benzodiazepines along with opioids for patients with chronic pain. When used in conjunction with opioid pain medications, benzodiazepines have been shown to enhance pain relief, but the combination can be accompanied by increased risks for abuse and accidental overdose. Given the increasing and widespread use of benzodiazepines, both alone and in conjunction with other medications, it is important for clinicians to use and understand urine drug screen (UDS) to fully manage patients. UDS results can help optimize treatment by providing information about the presence of possibly illicit or non-prescribed drug use. However, clinicians need to be aware that false positive results can occur, necessitating confirmatory testing. 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Method Urine drug.